Adenine → 8-Benzo(a)pyren-6-ylguanine

HRID 1458195Notes

Reaction equation

HRID 1458195 reaction equation
N1C(N)=C2C(N=CN2)=NC=1.[NH:11]1[C:20](=[O:21])[C:19]2[NH:18][CH:17]=[N:16][C:15]=2[N:14]=[C:12]1[NH2:13].O[CH:23]1[C:28]2=[CH:29][C:30]3[CH:31]=[CH:32][C:33]4[C:42]5[C:41]=3[C:40]([CH:39]=[CH:38][C:37]=5[CH:36]=[CH:35][CH:34]=4)=[C:27]2[CH:26](N2C3C(=O)NC(N)=NC=3N=C2)[CH:25](O)[CH:24]1O>>[CH:36]1[C:37]2=[C:42]3[C:41]4[C:40]([CH:39]=[CH:38]2)=[C:27]2[CH:26]=[CH:25][CH:24]=[CH:23][C:28]2=[C:29]([C:17]2[NH:18][C:19]5[C:20](=[O:21])[NH:11][C:12]([NH2:13])=[N:14][C:15]=5[N:16]=2)[C:30]=4[CH:31]=[CH:32][C:33]3=[CH:34][CH:35]=1

Participants

4

Reactant 3

HCID 190AdenineHCID 135398634GuanineHCID 1356252647-(7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo(a)-pyren-10-yl)guanine

Product 1

HCID 1356108758-Benzo(a)pyren-6-ylguanine

Procedure

##STR3## wherein R is adenine or guanine. The following compounds are exemplary: 7-(7,8,9-trihydroxy-7,8,9,10tetrahydrobenzo[a]pyren-10-yl)guanine, and

Sources & evidence

ORD record
ord-1de8b11cc2904a47b123d95b2dd42f9a
Source dataset
uspto-grants-1998_12
Patent number
US05849906

Reaction notes

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