2,3,6-Trichloro-5-(trifluoromethyl)pyridine → 2,5-Dichloro-6-methoxy-3-trifluoromethylpyridine

Participants

Reaction Conditions

Reaction Steps

10.8 g (0.06 mol) of 30% strength sodium methylate solution were added with stirring at 0°-5° C. in the course of 20 minutes to 15 g (0.06 mol) of 2,3,6-trichloro-5-trifluoromethylpyridine in 200 ml of methyl tert-butyl ether, and stirring was continued for 30 minutes at the same temperature. After the mixture had been heated to 20° C., the fine precipitate which had formed was filtered off with suction and washed using methyl tert-butyl ether. The organic filtrate was washed with water, dried and concentrated, giving 14.3 g (97% of theory) of the title compound of η25D =1.4890 (Table III, No. 3.001).

Provenance & Evidence