Ammonia → HCID 22101792, compound

HRID 1458243Notes

Reaction equation

HRID 1458243 reaction equation
[NH3:1].[Cl:2][C:3]1[C:4]([O:14][CH2:15][C:16]#[CH:17])=[N:5][C:6](F)=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1>>[NH2:1][C:6]1[C:7]([C:9]([F:12])([F:11])[F:10])=[CH:8][C:3]([Cl:2])=[C:4]([O:14][CH2:15][C:16]#[CH:17])[N:5]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 18689507HCID 18689507, compound

Product 1

HCID 22101792HCID 22101792, compound

Procedure

Starting from 3.1 g (0.182 mol) of ammonia and 10 g (0.039 mol) of 3-chloro-6-fluoro-2-propargyloxy-5-trifluoromethylpyridine, 4.1 g (42.3% of theory) of the title compound of m.p. 56°-58° C. (Table II, No. 2.035) and 2.7 g (27% of theory) of reisolated starting material were obtained after stirring for 3 hours at 110° C. under the same conditions as described in Example III.4.

Sources & evidence

ORD record
ord-f15a6fb7e12d4d1f91cb3df6ddc2ea23
Source dataset
uspto-grants-1998_12
Patent number
US05849920

Reaction notes

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