反应详情

To a mixed solution of toluene (8 ml) and methanol (12 ml) were added 1,2-bis(4- methoxyphenylmethyl)hydrazine dihydrochloride (0.99 g) and 1,3- dimorpholino-2-nitropropane (0.75 g). The mixture was refluxed with heating for 3 hours. The reaction solution was concentrated under a vacuum, purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1), thereby yielding 0.88 g (86%) of 1,2-bis (4-methoxyphenylmethyl)-4-nitropyrazolidine.

1. temperatureThe mixture was refluxed
2. temperaturewith heating for 3 hours
3. concentrationThe reaction solution was concentrated under a vacuum
4. custompurified by silica gel column chromatography (n-hexane:ethyl acetate=3:1)