反应详情

To a solution of 4-amino-1,2-bis(4-methoxyphenylmethyl)pyrazolidine (0.80 g) in tetrahydrofuran anhydride (20 ml) was added 4-geranyloxybenzoylimidazole (0.79 g). The mixture was stirred at room temperature for one night. The reaction solution, with water added thereto, was extracted with ethyl acetate. The extract was concentrated under a vacuum and the residue was purified by silica gel column chromatography (chloroform) and then recrystallized from ethyl acetate, thereby yielding 0.65 g (45%) of the aimed compound.

1. extractionwas extracted with ethyl acetate
2. concentrationThe extract was concentrated under a vacuum
3. customthe residue was purified by silica gel column chromatography (chloroform)
4. customrecrystallized from ethyl acetate