Dicyclohexylcarbodiimide → HCID 22101917, compound

Participants

Reaction Steps

To a solution of 4-geranyloxyphenylacetic acid (1.50 g) in tetrahydrofuran anhydride (30 ml) were added 1- hydroxybenzotriazole (0.85 g), N,N'- dicyclohexyl carbodiimide (1.29 g), and 4-amino-1,2- diethylpyrazolidine (0.75 g) while being cooled with ice and then the mixture was stirred for 6 hours at room temperature. The reaction solution was filtered so as to filter out the deposited product and the filtrate was concentrated under a vacuum. The residue was purified by silica gel column chromatography (chloroform:methanol=20:1), thereby yielding 2.05 g (95%) of the aimed compound.

Provenance & Evidence