反应详情

温度

50 °C

In a 50-ml autoclave, 1.0 g of 4-(4-fluoro-3 -methylphenyl)-4-oxobutanoic acid and 2.5 ml of methanol were charged, followed by the addition of 0.1 g of 10% palladium-carbon. After hydrogen pressure was increased to 30 kg/cm2 at room temperature, the resulting mixture was stirred at 50° C. for 3.5 hours. After the completion of the reaction, the reaction mixture was filtered, followed by washing with methanol. The filtrate was thereafter concentrated under reduced pressure. Water was added to the residue so obtained. The crystals so precipitated were filtered, washed with water and dried under reduced pressure, whereby 0.82 g of the title compound was obtained.

1. customAfter the completion of the reaction
2. filtrationthe reaction mixture was filtered
3. washby washing with methanol
4. concentrationThe filtrate was thereafter concentrated under reduced pressure
5. additionWater was added to the residue
6. customso obtained
7. customThe crystals so precipitated
8. filtrationwere filtered
9. washwashed with water
10. customdried under reduced pressure