Diethyl Ether → HCID 23211915, compound

HRID 1458318Notes

Reaction equation

HRID 1458318 reaction equation
[C:1]([O:4][CH2:5]/[C:6](/[C:17]1[CH:22]=[CH:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:19][CH:18]=1)=[C:7](/[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)\[C:8]([OH:10])=[O:9])(=[O:3])[CH3:2].[CH3:27]COCC>>[C:1]([O:4][CH2:5]/[C:6](/[C:17]1[CH:22]=[CH:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:19][CH:18]=1)=[C:7](/[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)\[C:8]([O:10][CH3:27])=[O:9])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 3283Diethyl Ether2×HCID 11617716(Z)-4-Acetoxy-3-(4-(methylsulfonyl) phenyl)-2-phenylbut-2-enoic acid

Product 1

HCID 23211915HCID 23211915, compound

Procedure

To a suspension of the acid from Example 4 (100 mg) in Et2O (20 mL) was added dropwise excess CH2N2 solution in Et2O. The solution was concentrated and the solid was swished with 2:1 hexane/EtOAc to give 90 mg of the title compound as a white solid.

Workup

  1. concentrationThe solution was concentrated

Sources & evidence

ORD record
ord-e4e347eae7864fd3a3aee259b5fbb0b7
Source dataset
uspto-grants-1998_12
Patent number
US05849943

Reaction notes

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