反应详情

温度

77 °C

To a solution of N-{2-[2-(3,4-dimethoxyphenyl)-1H-indol-3-yl]ethyl}-3-(1H-indol-5-yl)propionamide (60 mg in 2.0 mL dry tetrahydrofuran) at 0° C. was added 26 mg lithium aluminum hydride and the mixture heated to 77° C. on an oil bath. After 5.5 hours, the mixture was cooled to 0° C. and quenced by the addition of 0.025 mL water and stirred vigorously for 30 minutes at which time the suspension was filtered through a pad of sodium sulfate and the filtrate concentated in vacuo. Purification by flash chromatography (methylene chloride:methanol, 92:8) gave the title compound (32 mg). m/e=454 (M+H)

1. temperaturethe mixture was cooled to 0° C.
2. filtrationwas filtered through a pad of sodium sulfate
3. customPurification by flash chromatography (methylene chloride:methanol, 92:8)