Lithium tri-s-butylborohydride → HCID 178520419, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(1H-benzoimidazol-5-yl)-acrylic acid methyl ester (50 mg in 1 mL dry tetrahydrofuran) at -78° C. was added 1.24 nL of a 1M solution of lithium tri-sec-butylborohydride in tetrahydrofuran and the mixture stirred at -78° C. for 4 hours followed by warming to -40° C. for an additional 4 hours. The reaction was quenched by addition of aqueous methanol, concentrated in vacuo and purified by flash chromatography on silica gel (methylene chloride:methanol, 87:13) to give the title compound (44 mg).

Provenance & Evidence