Hydrochloric Acid → HCID 67666025, compound

Participants

Reaction Steps

A solution of 452 mg (0.914 mmol) of 2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-4-yl)butylamino]ethyl]-1H-indole-5-carboxylic acid diethylamide in 45 mL of methanol was treated with 1.83 mL (3.66 mmol) of 2N hydrochloric acid. After a few minutes, the solution was evaporated to dryness. The residue was reconcentrated from methanol and then triturated with diethyl ether. The solid was collected on a filter, washed with additional diethyl ether, and dried to give 455 mg (87%) of yellowish powder, mp 154°-157° C. 500 MHz 1H NMR (DMSO-d6) was consistent with the assigned structure.

Provenance & Evidence