Bromine → Phenol, 4-bromo-2,3,6-trifluoro-

HRID 1458380Notes

Reaction equation

HRID 1458380 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[OH:10].[Br:11]Br>ClCCl>[Br:11][C:6]1[CH:5]=[C:4]([F:9])[C:3]([OH:10])=[C:2]([F:1])[C:7]=1[F:8]

Participants

4

Reactant 2

HCID 24408BromineHCID 5179882,3,6-Trifluorophenol

Product 1

HCID 12182317Phenol, 4-bromo-2,3,6-trifluoro-

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

10 g (0.0678 mol) of 2,3,6-trifluorophenol (prepared according to Examples 1a and 1b) are dissolved in 50 ml of dichloromethane, and this solution is admixed at 20° C. with 13 g (0.0811 mol) of bromine. After mixing by shaking, the mixture is left standing for 7 days.

Workup

  1. additionAfter mixing
  2. waitthe mixture is left

Sources & evidence

ORD record
ord-f70c677834b9456f9880a1d26bf3aaf7
Source dataset
uspto-grants-1998_12
Patent number
US05849959

Reaction notes

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