HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 14584Generated: October 25, 2026
rel-(2R,6S)-2,6-Dimethylpiperidine → HCID 86607467, compound
https://huagongshe.com/reaction/14584
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | rel-(2R,6S)-2,6-Dimethylpiperidine | HCID 641768 | — |
| Reactant | 4,6-Dichloro-5-fluoropyrimidine | HCID 11286675 | — |
| Product | HCID 86607467 | HCID 86607467 | 57.5% |
Reaction Steps
0.25 g of 4,6-dichloro-5-fluoropyrimidine and 0.34 g of cis-2,6-dimethylpiperidine were mixed and stirred for 11 hours at 70° C. The reaction mixture was subjected to silica gel column chromatography to obtain 0.21 g of 4-chloro-6-(cis-2,6-dimethylpiperidino)-5-fluoropyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07732448B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-0817df69e5fb453f85648bdb00310dde |
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| Source note | uspto-grants-2010_06 |
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