Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | 2-Methyl-6-hydroxy-5-methoxycarbonylbenzimidazole | HCID 22100697 | — |
| Reactant | HCID 178497327 | HCID 178497327 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 53892148 | HCID 53892148 | — |
| Product | HCID 54327588 | HCID 54327588 | — |
Reaction Steps
To a mixture of 2-methyl-6-hydroxy-5-methoxycarbonylbenzimidazole and 2-methyl-4-hydroxy-5-methoxycarbonylbenzimidazole (7.2 g) in THF (50 mL) was added di-tert-butyldicarbonate (7.6 g) and triethylamine (5 mL). After stirring at 50° C. for 6 hours the solvent was removed and the residue was triturated with ethyl acetate and filtered to afford 1-tert-butoxycarbonyl-2-methyl-6-hydroxy-5-methoxycarbonylbenzimidazole and 1-tert-butoxycarbonyl-2-methyl-4-hydroxy-5-methoxycarbonylbenzimidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05849759 |
|---|
| Source dataset | uspto-grants-1998_12 |
|---|
| ORD ID | ord-80433fa3809647afba3adb1ed8d38841 |
|---|
| Source note | uspto-grants-1998_12 |
|---|
