HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → HCID 178439970, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Reactant | Diethyl azodicarboxylate | HCID 5462977 | — |
| Reactant | HCID 22100814 | HCID 22100814 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178439970 | HCID 178439970 | — |
Reaction Steps
To a solution of 2-isopropyl-6-hydroxy-5-nitrobenzimidazole and the HBr addition product (15 g), N-tert-butoxycarbonyl-4-hydroxypiperidine (17.7 g), PPh3 (23.1 g), and THF (150 mL) at room temperature was added DEAD (14 mL). After 4 hours, the solvent was removed in vacuo and the product recovered from the crude using chromatography (3% methanol/methylene chloride) to yield 2-isopropyl-5-(N-(tert-butoxycarbonyl)piperidin-4-yloxy)-6-nitrobenzimidazole (16.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849759 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-b1d1e29c521b49bdb7d537fc0726163f |
| Source note | uspto-grants-1998_12 |