Fumaric Acid → HCID 67623101, compound

HRID 1458533Notes

Reaction equation

HRID 1458533 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH:9]([N:16]2[CH2:20][CH:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[O:18][C:17]2=[O:27])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:3][CH2:2]1.[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32]>C(O)C>[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32].[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH:9]([N:16]2[CH2:20][CH:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[O:18][C:17]2=[O:27])[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 53927178HCID 53927178, compound

Product 1

HCID 67623101HCID 67623101, compoundYield 61.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Diastereomer A of 3-(3-morpholino-1-phenylpropyl)-5-phenyl-1,3-oxazolidin-2-one (480 mg, 1.31 mmol) prepared in the same manner as is described in Example 7 and fumaric acid (152 mg, 1.31 mmol) were dissolved in ethanol (30 ml). The resulting solution was concentrated by distillation under reduced pressure to obtain 389 mg of the titled compound as a pale yellow amorphous product (yield: 61.5%)

Workup

  1. concentrationThe resulting solution was concentrated by distillation under reduced pressure

Sources & evidence

ORD record
ord-cf87b57e68e544f49ea1e7f51061811c
Source dataset
uspto-grants-1998_12
Patent number
US05852006

Reaction notes

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