Fumaric Acid → HCID 67623235, compound

HRID 1458536Notes

Reaction equation

HRID 1458536 reaction equation
[CH2:1]([CH:8]1[O:12][C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH:16]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33]>C(O)C>[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33].[CH2:1]([CH:8]1[O:12][C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH:16]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 545585415-Benzyl-3-[3-(morpholin-4-yl)-3-phenylpropyl]-1,3-oxazolidin-2-one

Product 1

HCID 67623235HCID 67623235, compoundYield 100.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-benzyl-3-(3-morpholino-3-phenylpropyl) -1,3-oxazolidin-2-one (0.26 g, 0.68 mmol) prepared in the same manner as is described in Example 9 and fumaric acid (0.08 g, 0.68 mmol) were dissolved in ethanol. From the resulting solution, ethanol was removed by distillation under reduced pressure. Water was added to the residue and then the resulting solution was concentrated. After the concentration was repeated for three times, the residue was dried in vacuum to obtain 0.34 g of the titled compound as a pale scarlet amorphous product (yield: 100%).

Workup

  1. customFrom the resulting solution, ethanol was removed by distillation under reduced pressure
  2. additionWater was added to the residue
  3. concentrationthe resulting solution was concentrated
  4. concentrationAfter the concentration
  5. customthe residue was dried in vacuum

Sources & evidence

ORD record
ord-2a7c8c6a872a4cfe977c44fb6bcc481c
Source dataset
uspto-grants-1998_12
Patent number
US05852006

Reaction notes

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