Nitric Acid → HCID 9816093, compound

Participants

Reaction Conditions

Reaction Steps

1,4-Dihydro-6,7-dimethylquinoxalin-2,3-dione (10.0 g, 52.6 mmol --see J. Liebigs Ann. Chem., 1982, 754-761) was added in portions over 10 minutes to concentrated nitric acid (density, 1.42 gcm-3, 100 ml) at 0° C. After 5 minutes, the cooling bath was removed and the mixture was stirred at 20° C. for 7 hours, using cooling when necessary. The solution was poured into iced water, and the resulting solid filtered off and dried in vacuo at 75° C. to give 1,4-dihydro-6,7-dimethyl-5-nitroquinoxalin-2,3-dione (7.44 g, 60%) as a pale yellow solid, m.p. 280-290° C. (dec.) from dimethylformamide/water).

Provenance & Evidence