Tetrahydrofuran → HCID 53844231, compound

Participants

Reaction Conditions

Reaction Steps

Sodium methoxide (25% solution in methanol, 13.9 ml, 61 mmol) was added over 12 minutes to a stirred solution of 5-amino-2,3-dichloro-6,7-dimethylquinoxaline (from step (c), 6.15 g, 25.4 mmol) in dry tetrahydrofuran (250 ml) under nitrogen at 0° C. The mixture was stirred at 0° C. for 20 minutes, and at room temperature for 72 hours. The mixture was diluted with ethyl acetate (750 ml), washed with water (2×250 ml) and brine (250 ml), dried (MgSO4), and concentrated under reduced pressure. The residue was purified by flash chromatography (gradient elution with hexane/dichloromethane) to give the title compound as a white solid (4.55 g, 77%), m.p. 166°-167° C.

Provenance & Evidence