HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole-3-carbonyl chloride → Quinolizidin-2-ylmethylindole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole-3-carbonyl chloride | HCID 12380278 | — |
| Reactant | Octahydro-2H-quinolizine-2-methanol | HCID 70077295 | — |
| Product | Quinolizidin-2-ylmethylindole-3-carboxylate | HCID 131719520 | — |
Reaction Steps
eq-2-Hydroxymethylquinolizidine (N.J. Leonard et al., J. Org. Chem., 1957, 22, 1445) was reacted with indole-3-carboxylic acid chloride using the method described in Example 1a to afford eq-quinolizidin-2-ylmethyl 1-H-indole-3-carboxylate mp 154°-157° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05852014 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-74052627e98344d18a11ce50e7d58671 |
| Source note | uspto-grants-1998_12 |