Cyclohexane, (bromomethyl)- → N-[(1-Cyclohexylmethyl-4-piperidyl)methyl] 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide

Participants

Reaction Steps

N-(4-Piperidylmethyl) 3,4-dihydro-2 H-[1,3]oxazino[3,2-a]indole- 10-carboxamide (E21) was alkylated with cyclohexylmethyl bromide using the method of Example 22 with a reaction time of 70 h at room temperature followed by 8 h at reflux temperature. The title compound (E23) was obtained as a white solid (31%) which was converted to its hydrochloride salt and crystallised from acetone/ether as a white solid mp 209°-210° C.

Provenance & Evidence