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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1458607Generated: October 26, 2026

1H-Indole-3-carbonyl chloride → 1H-indole-3-carboxamide

https://huagongshe.com/reaction/1458607

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-Indole-3-carbonyl chlorideHCID 12380278—
ReactantQuinolizidin-2-ylmethylamineHCID 82413010—
Product1H-indole-3-carboxamideHCID 219254255%

Reaction Steps

eq-Quinolizidin-2-ylmethylamine (D12) was reacted with indole-3-carboxylic acid chloride using the method of Description 1b) to afford N-(eq-quinolizidin-2-ylmethyl) indole-3-carboxamide as a white solid (55%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05852014
Source datasetuspto-grants-1998_12
ORD IDord-19b77b9cef19462f84c0fc992879c031
Source noteuspto-grants-1998_12