4-Aminomethyl-1-N-butylpiperidine → N-[(1-n butyl-4-piperidyl)methyl] 5-fluoroindole-3-carboxamide

HRID 1458609노트

반응식

HRID 1458609 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11](Cl)=[O:12].[CH2:14]([N:18]1[CH2:23][CH2:22][CH:21]([CH2:24][NH2:25])[CH2:20][CH2:19]1)[CH2:15][CH2:16][CH3:17]>>[CH2:14]([N:18]1[CH2:23][CH2:22][CH:21]([CH2:24][NH:25][C:11]([C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=3)[NH:7][CH:6]=2)=[O:12])[CH2:20][CH2:19]1)[CH2:15][CH2:16][CH3:17]

참가 물질

3

반응물 2

HCID 104421334-Aminomethyl-1-N-butylpiperidineHCID 543282495-Fluoroindole-3-carboxylic acid chloride

생성물 1

HCID 53789030N-[(1-n butyl-4-piperidyl)methyl] 5-fluoroindole-3-carboxamide수율 64%

실험 절차

5-Fluoroindole-3-carboxylic acid chloride was reacted with (1-n butyl-4-piperidyl)methylamine (Description 1a) as in the method of Description 1b to afford N-[(1-n butyl-4-piperidyl)methyl] 5-fluoroindole-3-carboxamide as an off-white solid (64%).

출처 및 근거

ORD 기록
ord-9b9bc9db12c64b889a09ae9539cd2e25
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05852014

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