Ethyl Acetate → (1-n Butyl-4-piperidyl)methyl-2,3-dihydrothiazolo[3,2-a]indole-9-Carboxylate

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Reaction Steps

The title compound was prepared from 2,3-dihydrothiazolo[3,2-a]indole-9carboxylic acid (D15) using the method of Example 10. The crude product was purified by chromatography on silica gel eluting with 5% methanol/chloroform to give a yellow oil. This was passed through a plug of basic alumina eluting with ethyl acetate to afford the title compound as a pale yellow oil (31%) which was converted to its oxalate salt and was crystallised from acetone as an off-white solid mp 212°-215° C.

Provenance & Evidence