Hydrochloric Acid → HCID 19599427, compound

Participants

Reaction Steps

A solution of ethyl 6,7,8,9-tetrahydro-1 H-pyrido[1,2-a]indole-10-carboxylate (1.20 g, 0.0047 mole) in ethanol (50 ml) and 10% NaOH solution (50 ml) was heated under reflux for 4 hours. The reaction was then acidified with 1M HCl acid (50 ml) and extracted with ethyl acetate (50 ml). The organic layer was separated and extracted with 10% Na2CO3 solution (120 ml) and the aqueous solution then re-acidified with 5M HCl acid and extracted into ethyl acetate (2×75 ml). The organic extracts were combined, dried (Na2SO4) and concentrated in vacuo to afford the title compound (D3) as a white solid (400 mg, 40%).

Provenance & Evidence