HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → Diethyl 2-chloropyrimidine-4,5-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178469856 | HCID 178469856 | — |
| Product | Diethyl 2-chloropyrimidine-4,5-dicarboxylate | HCID 21220647 | 30% |
Reaction Steps
The title compound was prepared as described in Example 7, but employing a solution of diethyl 2-hydroxypyrimidine-4,5-dicarboxylate (1.0 g, 4.2 mmol) and POCl3 (7.7 g, 50 mmol) resulting in a 30% yield (0.32 g); 1HNMR (CDCl3) δ 9.09 (d, 1H), 4.35 (m, 4H), 1.30 (m, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05852028 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-3e8e0ebe845542ea81fad923af3d74c6 |
| Source note | uspto-grants-1998_12 |