HCID 178437715, compound → HCID 178436600, compound

HRID 1458652Notes

Reaction equation

HRID 1458652 reaction equation
[CH2:1]([C:3]1[N:8]=[CH:7][N:6]=[C:5]([NH:9][C@H:10]2[CH2:15][CH2:14][C@@H:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)[C:4]=1[C:22]#[C:23][Si](C)(C)C)[CH3:2]>[OH-].[K+]>[C:22]([C:4]1[C:5]([NH:9][C@H:10]2[CH2:11][CH2:12][C@@H:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][CH2:15]2)=[N:6][CH:7]=[N:8][C:3]=1[CH2:1][CH3:2])#[CH:23]

Participants

3

Reactant 1

HCID 178437715HCID 178437715, compound

Product 1

HCID 178436600HCID 178436600, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

Prepared as in Example 6 from 6-ethyl-4-(cis-4-phenylcyclohexylamino)-5-trimethylsilylethynylpyrimidine (Example 9) by eliminating the silyl group in methanolic potassium hydroxide solution.

Sources & evidence

ORD record
ord-a0bfd86abd304ed591aeed050e0e6f72
Source dataset
uspto-grants-1998_12
Patent number
US05852023

Reaction notes

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