Hydroquinone → HCID 178437723, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 7.6 g (21 mmol) of 4-(cis-4-tert-butylcyclohexylamino)-5-chloro-6-(1-methylsulfinylethyl)pyrimidine (Example 26) in 100 ml of diethylene glycol dimethyl ether to which a little hydroquinone had been added was heated at 150° C. for 30 minutes. After cooling to room temperature the mixture was poured into water and extracted by stirring with dichloromethane. This left a brown oil which was extracted twice by stirring with petroleum ether. The petroleum ether phase was concentrated and the residue was purified with chromatography on silica gel, to give 1.1 g (17.8% of theory) of colorless solid.

Provenance & Evidence