反应详情

15.2 g (71 mmol) of methyl (4-chloro-6-methylpyrimidin-5-yl)acetate, 11.0 g (71 mmol) of cis-4-tert-butylcyclohexylamine and 20.2 g (0.2 mol) of triethylamine were heated at 80° to 90° C. for 6 hours without solvent. After cooling, the mixture was taken up in water/toluene and the organic phase was dried and concentrated. In the chromatography on silica gel (petroleum ether/ethyl acetate 1:1, then ethyl acetate/methanol 9:1), 5.3 g of chloropyrimidine starting material were first of all retained and then 10.0 g (27.7% of theory) of product were obtained as a yellow solid.

1. temperatureAfter cooling
2. customthe organic phase was dried
3. concentrationconcentrated
4. custom10.0 g (27.7% of theory) of product were obtained as a yellow solid