Triethylamine → HCID 54141581, compound

Participants

Reaction Steps

30.6 g (0.16 mol) of ethyl (4-hydroxy-6-methylpyrimidin-5-yl)acetate, 17.8 g (0.18 mol) of triethylamine and 263.2 g (1.72 mol) of phosphorus oxychloride were heated at reflux for 4 hours. The excess phosphorus oxychloride was stripped off, the residue was taken up in dichloromethane, and the mixture was added dropwise to 500 ml of sodium bicarbonate solution and neutralized by addition of solid sodium bicarbonate. The organic phase was separated off, dried and concentrated to give 30.4 g (88.5% of theory) of a dark oil which was reacted further without purification.

Provenance & Evidence