Water → HCID 178437722, compound

Participants

Reaction Steps

0.64 g (1.76 mmol) of 4-(cis-4-tert-butylcyclohexylamino)-5-chloro-6-trimethylsilylethynylpyrimidine (Example 27) was dissolved in 20 ml of tetrahydrofuran, and 2 ml of a 1.0M solution of tetrabutylammonium fluoride in tetrahyrofuran were added at 0° C. The mixture was stirred at room temperature for 2 hours, diluted with toluene and exracted by stirring with sodium hydrogen carbonate solution and water. The organic phase was dried and concentrated. Chromatography on silica gel left 0.44 g (86.0% of theory) of a colorless oil which gradually solidified.

Provenance & Evidence