Sodium Methoxide → HCID 178437717, compound

Participants

Reaction Steps

7.20 g (20 mmol) of 5-bromo-6-ethyl-4-(cis-4-phenylcyclohexylamino)pyrimidine (DE-A-42 08 254) and 0.44 g (3 mmol) of copper(I) bromide were heated under reflux for 12 hours in 10 ml of 30% methanolic sodium methylate solution, to which 0.70 g of ethyl acetate have been added. For working up, the solvent is stripped off, the residue is taken up in ethyl acetate, this mixture is subjected to extraction by stirring with water, and the organic phase is dried and concentrated. For purification, the crude product is chromatographed on silica gel using ethyl acetate/petroleum ether (8:2). 3.7 g (60% of theory) of a colorless oil were obtained which gradually solidified.

Provenance & Evidence