1,2-Dichloroethane → HCID 22096813, compound

Participants

Reaction Steps

Thionyl chloride (3.17 g; 26.6 mmol) was added dropwise under ice cooling to a solution of 2.39 g (8.87 mmol) of methyl 4-[N,N-bis(2-hydroxyethyl)amino]phenoxyacetate in 72 ml of 1,2-dichloroethane. The thus-obtained mixture was stirred at room temperature for 4 hours and then concentrated. The resulting residue was purified by flush chromatography (chloroform/methanol=200/3), whereby 2.0 g of the title compound were obtained as brown crystals (yield: 74%).

Provenance & Evidence