HCID 15907743, compound → HCID 15907744, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1.59 g (3.82 mmol) of methyl 3,5-bis[N,N-bis(2-chloroethyl)amino]benzoate in 48 ml of concentrated hydrochloric acid was heated at 50° C. for 5 hours. After completion of the reaction, the suspension was extracted with methylene chloride. The extract was washed with an aqueous solution of sodium hydrogencarbonate and then with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate, and was then concentrated. The resultant residue was purified by flush chromatography (methanol/chloroform=1/20), whereby 1.01 g of the title compound were obtained as colorless crystals.

Provenance & Evidence