Acetic Acid → HCID 22096954, compound

Participants

Reaction Steps

Methyl 4-aminophenylacetate (5.5 g; 33 mmol) was reacted with 45 g (341 mmol, 10 equivalents) of ethylene oxide in 33 ml of 30% acetic acid, followed by post treatments. The crude product so obtained was purified by chromatography on a silica gel column (n-hexane/ethyl acetate=1/2→1/4) and washed with n-hexane, whereby 6.07 g (24.0 mmol) of the title compound were obtained as white crystals (yield: 72.6%).

Provenance & Evidence