Methyl 3-methoxy-4-nitrobenzoate → Methyl 4-amino-3-methoxybenzoate

Participants

Reaction Steps

Methyl 3-methoxy-4-nitrobenzoate (4.8 g; 23 mmol) was dissolved in 150 ml of a 2:1 mixed solvent of methanol and tetrahydrofuran, followed by addition of 480 mg of 5% Pd/C. The resulting mixture was stirred for 2 hours under a hydrogen gas atmosphere at room temperature. After completion of the reaction, the Pd/C was filtered off and the solvent was distilled out under reduced pressure, whereby 3.9 g of white crystals were obtained (yield: 54%).

Provenance & Evidence