反应详情

To 10 g (72 mmol) of 3-nitroaniline, 10 ml (106 mmol) of acetic anhydride were added, followed by stirring. White crystals were precipitated with exotherm. After stirring for 10 minutes, ice water was poured into the reaction mixture. The crystals were dissolved in chloroform, followed by washing successively with 1N hydrochloric acid, a saturated aqueous solution of sodium hydrogencarbonate and saturated saline. The organic layer was dried over anhydrous magnesium sulfate and then the solvent was distilled out under reduced pressure. The residue was washed with ethyl ether, whereby 11.6 g of white powder were obtained (yield: 89%).

1. customWhite crystals were precipitated with exotherm
2. stirringAfter stirring for 10 minutes
3. additionice water was poured into the reaction mixture
4. dissolutionThe crystals were dissolved in chloroform
5. washby washing successively with 1N hydrochloric acid
6. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
7. distillationthe solvent was distilled out under reduced pressure
8. washThe residue was washed with ethyl ether