2-(Ethylamino)ethanol → HCID 13797249, compound

HRID 1458720Notes

Reaction equation

HRID 1458720 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[CH2:11]([NH:13][CH2:14][CH2:15][OH:16])[CH3:12]>CS(C)=O>[CH2:11]([N:13]([C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1)[CH2:14][CH2:15][OH:16])[CH3:12]

Participants

4

Reactant 2

HCID 80722-(Ethylamino)ethanolHCID 9590p-Fluoronitrobenzene

Product 1

HCID 13797249HCID 13797249, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
140 °C

Procedure

In 30 ml of DMSO, 5.0 g (35.4 mmol) of 4-fluoronitrobenzene and 6 g (67.3 mmol) of 2-(ethylamino)ethanol were dissolved. The resultant solution was stirred under heat at 140° C. for 4 hours, followed by extraction with ethyl acetate. The solvent was distilled out under reduced pressure, followed by washing with ethyl acetate, whereby 6.3 g of yellow powder were obtained (yield: 85%).

Workup

  1. extractionfollowed by extraction with ethyl acetate
  2. distillationThe solvent was distilled out under reduced pressure
  3. washby washing with ethyl acetate

Sources & evidence

ORD record
ord-40ed946b471c446e95d31bde7e2ee0d1
Source dataset
uspto-grants-1998_12
Patent number
US05852011

Reaction notes

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