4-Methoxy-2-nitrobenzoic acid → 2-Amino-4-methoxybenzoic acid

Participants

Reaction Steps

2-Nitro-4-methoxybenzoic acid (43.4 g, 0.22 mol) in DMF (250 ml) is hydrogenated at 55 psi in the presence of 10% palladium on carbon (5.8 g) for 2.5 hours. The reaction mixture is filtered through SUPERCELL™, the filter cake is rinsed with ethanol, and then the filtrate is poured into ice water (3.5 L). A precipitate forms which is collected by filtration, washed with water and dried in an oven at 60° C. to afford 30.7 g (84%) of 4-methoxyanthranilic acid, m.p. 176°-178° C. (dec.).

Provenance & Evidence