Pyridinium chloride → HCID 70087059, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-ethyl-N-(3-methoxyphenylmethyl)-1H-pyrazolo[3,4-b]quinolin-4-amine (3.8 g, 0.0114 mol) and pyridine hydrochloride (10 g) is heated at about 200° C. for 3 hours. The reaction mixture is cooled and then 10% NaOH (70 ml) is added. The mixture is washed with ether (2×30 ml) and then the aqueous layer is acidified with acetic acid to a pH of about 5. The solid which formed is collected by filtration and dried in vacuo to afford 2.5-3 g of 1-ethyl-N-(3-hydroxyphenylmethyl)-1H-pyrazolo[3,4-b]quinolin-4-amine, as an off-white solid, m.p. 273°-275° C.

Provenance & Evidence