Dimethyl Sulfoxide → HCID 67587896, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-ethyl-4-chloro-1H-pyrazolo[3,4-b]-quinoline (1.0 g, 0.0043 mol), DMSO (1 ml) and 3-aminomethylpyridine (0.97 ml, 0.0093 mol) is heated at 90° C. for 4 hours. The reaction mixture is poured into water, and the solid that forms is collected by filtration and recrystallized from ether/CH2Cl2/hexane to afford the product as the free base. The free base is dissolved in methanol (100 ml) and then is treated with methanesulfonic acid (1 ml). The methanol is evaporated, and then the residue is crystallized from 2-propanol/ether. The product is collected by filtration, washed with ether and dried in vacuo to afford 1.0 g of 1-ethyl-N-(3-pyridinylmethyl)-1H-pyrazolo[3,4-b]quinolin-4-amine.2CH3SO3H, m.p. 282°-284° C.

Provenance & Evidence