Dimethyl Sulfoxide → HCID 67586737, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-ethyl-4-chloro-1H-pyrazolo[3,4-b]quinoline (1.0 g, 0.0043 mol), DMSO (3 ml) and 1-aminoindane (1 g) is heated at 110° C. for 16 hours. The reaction mixture is cooled, and then is poured into water (100 ml). The solid that forms is collected by filtration and dried to afford the product as the free base. The free base is dissolved in methanol and then is treated with methanesulfonic acid. The methanol is evaporated, and the residue is crystallized from hot methanol/2-propanol and then is recrystallized from hot methanol/2-propanol to afford 717 mg of 1-ethyl-N-(1-indanyl)-1H-pyrazolo[3,4-b]quinolin-4-amine.CH3SO3H, m.p. 233°-235° C.

Provenance & Evidence