HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2,5-dimethoxyoxolane-2-carboxylate → 1-Cyclohexyl-6-trifluoromethyl-7-(2-methoxycarbonyl-1-pyrrolyl)-2,3(1H,4H)-quinoxalinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2,5-dimethoxyoxolane-2-carboxylate | HCID 13152840 | — |
| Reactant | 1-cyclohexyl-6-trifluoromethyl-7-amino-2,3(1H,4H)-quinoxalinedione | HCID 22097117 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | 2,5-Dimethoxytetrahydrofuran | HCID 79098 | — |
| Product | 1-Cyclohexyl-6-trifluoromethyl-7-(2-methoxycarbonyl-1-pyrrolyl)-2,3(1H,4H)-quinoxalinedione | HCID 22097228 | — |
Reaction Steps
In place of 2,5-dimethoxytetrahydrofuran, 1.2 g (6.1 mmol) of 2-methoxycarbonyl-2,5-dimethoxytetrahydrofuran were dissolved with 2 g (6.1 mmol) of 1-cyclohexyl-6-trifluoromethyl-7-amino-2,3(1H,4H)-quinoxalinedione in 100 ml of acetic acid and refluxed for 30 minutes. The mixture was then worked up as in Example 3f.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05852017 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-54097fc6617a49e38877261bda276948 |
| Source note | uspto-grants-1998_12 |