HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Acetate → 6-(2-methoxycarbonyl-1-pyrrolyl)-7-nitro-2,3(1H,4H)-quinoxalinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 6-Amino-7-nitroquinoxaline-2,3-diol | HCID 3980992 | — |
| Reactant | Methyl 2,5-dimethoxyoxolane-2-carboxylate | HCID 13152840 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-(2-methoxycarbonyl-1-pyrrolyl)-7-nitro-2,3(1H,4H)-quinoxalinedione | HCID 22097080 | — |
Reaction Steps
7 g (27.1 mmol) of 6-amino-7-nitro-2,3(1H,4H)-quinoxalinedione, 5.1 g (27.1 mmol) of 2-methoxycarbonyl-2,5-dimethoxytetrahydrofuran and 4.5 g (54.2 mmol) of sodium acetate in 500 ml of glacial acetic acid were refluxed for one hour. The reaction mixture was concentrated and then the crude product was purified by column chromatography on silica gel (mobile phase: toluene/acetone/glacial acetic acid=10/10/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05852017 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-21831a645dfa41f190aaa3891d82f397 |
| Source note | uspto-grants-1998_12 |