Ethanol → HCID 22097137, compound

HRID 1458828Notes

Reaction equation

HRID 1458828 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([NH:16]C(=O)C(OCC)=O)=[C:10]([N+:13]([O-:15])=[O:14])[CH:11]=2)[NH:6][C:5](=[O:24])[C:4]1=[O:25])[CH3:2].O.C(O)C>S(=O)(=O)(O)O>[NH2:16][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][C:10]=1[N+:13]([O-:15])=[O:14])[N:3]([CH2:1][CH3:2])[C:4](=[O:25])[C:5](=[O:24])[NH:6]2

Participants

5

Reactant 3

HCID 702EthanolHCID 962WaterHCID 22097179HCID 22097179, compound

Product 1

HCID 22097137HCID 22097137, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

24 g (68.6 mmol) of this amide were refluxed in a mixture of 13 ml of concentrated sulfuric acid, 240 ml of water and 250 ml of ethanol for 3 h. The precipitate was then filtered off with suction to yield 16.2 g (98%) of the product.

Workup

  1. filtrationThe precipitate was then filtered off with suction

Sources & evidence

ORD record
ord-0d580dbf55e147d69c4e19a531e81895
Source dataset
uspto-grants-1998_12
Patent number
US05852017

Reaction notes

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