HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2(1H)-quinolone-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | 2-Amino-4,5,3',4'-tetramethoxybenzophenone | HCID 9926967 | — |
| Catalyst | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2(1H)-quinolone-3-carboxylate | HCID 22097611 | 92.1% |
Reaction Conditions
| Temperature | 180 °C |
|---|
Reaction Steps
A mixture of 2-amino-4,5,3',4'-tetramethoxybenzophenone (10.0 g), diethyl malonate (6.0 g) and 1,8-diazabicyclo[5.4.0]-7-undecene (DBU)(0.396 g) was stirred at 180° C. for 10 minutes. After cooling, ethanol was added to the reaction mixture, and the crystals were collected by filtration to give ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2(1H)-quinolone-3-carboxylate (12.0 g, 91%) which was then recrystallized from chloroform-acetone. mp. 273°-276° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05852039 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-3afc6ccaa4fd48dabe9e9af0204789f9 |
| Source note | uspto-grants-1998_12 |