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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1458946Generated: October 31, 2026

Lawesson's reagent → HCID 178470133, compound

https://huagongshe.com/reaction/1458946

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLawesson's reagentHCID 87949—
Reactantethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2(1H)-quinolone-3-carboxylateHCID 22097611—
SolventTolueneHCID 1140—
ProductHCID 178470133HCID 17847013370.8%

Reaction Steps

A mixture of ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2(1H)-quinolone-3-carboxylate (6.8 g), Lawesson's reagent (8.0 g) and toluene (250 ml) was stirred under reflux for 18 hours. After cooling, the precipitated crystals were collected by filtration to give ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-mercaptoquinoline-3-carboxylate (5.0 g, 70%) which was then recrystallized from acetone. mp. 265°-266° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05852039
Source datasetuspto-grants-1998_12
ORD IDord-7f3fe5a1d07740108998c9bc56a48268
Source noteuspto-grants-1998_12