HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Vinylpyridine → N-Ethylpyridin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Vinylpyridine | HCID 7521 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | N-Ethylpyridin-4-amine | HCID 12661197 | — |
Reaction Steps
A slurry of vinyl pyridine (161.4 mL, 1.5 mol) and ammonium chloride (240.7 g, 4.5 mol) in 1:1 MeOH/H2O (1.2 L) was heated to reflux for 18 h. The resulting homogenous solution was basified to pH13 with 3N NaOH and extracted repeatedly with CH2Cl2. The organic extracts were combined and concentrated to give a green oil, which was fractionally distilled to give 2-1 as an amber liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05852045 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-6e3c1c1c2a09487daa176db3e6ad279c |
| Source note | uspto-grants-1998_12 |