HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Tetrachloride → 4-(3-Chloropropyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Tetrachloride | HCID 5943 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 1-(Pyridin-3-yl)propan-1-ol | HCID 11083942 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(3-Chloropropyl)pyridine | HCID 205442 | — |
Reaction Steps
A solution of 3-pyridylpropanol (2-2) (ICN Biochemicals, 14.2 g, 0.1 mol) in THF (200 mL) was treated successively with triphenylphosphine (47.2 g, 0.18 mol) and carbontetrachloride (17.4 mL, 0.18 mol) and stirred for 24 h. The reaction was filtered and the solids washed with Et2O. The filtrate was concentrated to give a yellow solid which was triturated with Et2O. Chromatography (silica gel, 30% EtOAc/Hexanes) gave 2-3 as yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05852045 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-971b659f5de24d80b7911e97c66389be |
| Source note | uspto-grants-1998_12 |