HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydroisoquinoline Hydrochloride → 1-[5-Methyl-1-(4-methyl-6-methoxy-2-pyrimidinyl)-4-pyrazolyl]-3-[4-(2-methylphenyl)-1-piperazinyl]-1-trans-propene hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydroisoquinoline Hydrochloride | HCID 2734717 | — |
| Reactant | 1-(o-Tolyl)piperazine Hydrochloride | HCID 12227895 | — |
| Reactant | 1-(2-Pyrimidinyl)-4-acetyl-5-methylpyrazole | HCID 15456375 | — |
| Reactant | 1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)-1-propanone hydrochloride | HCID 22097301 | — |
| Reactant | 1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)-1-trans-propene hydrochloride | HCID 22097305 | — |
| Reactant | 1-(4-Methyl-6-methoxy-2-pyrimidinyl)-4-acetyl-5-methylpyrazole | HCID 22097343 | — |
| Product | 1-[5-Methyl-1-(4-methyl-6-methoxy-2-pyrimidinyl)-4-pyrazolyl]-3-[4-(2-methylphenyl)-1-piperazinyl]-1-trans-propene hydrochloride | HCID 22097312 | — |
Reaction Steps
The procedures of Example 6 (1) and (2) were repeated but substituting the 1-(2-pyrimidinyl)-4-acetyl-5-methylpyrazole and 1,2,3,4-tetrahydroisoquinoline hydrochloride employed in Example 6 (1) respectively by 1-(4-methyl-6-methoxy-2-pyrimidinyl)-4-acetyl-5-methylpyrazole and 1-(2-methylphenyl)piperazine hydrochloride. After the completion of the post treatment, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05852019 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-db7af0a0c5f14de4b55a0c6772f87793 |
| Source note | uspto-grants-1998_12 |